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Which arterial blood gas interpretation best describes metabolic acidosis?

  1. pH elevated, pCO2 elevated, H2CO3 normal range

  2. pH decreased, pCO2 decreased, H2CO3 low

  3. pH decreased, pCO2 elevated, H2CO3 normal range

  4. pH elevated, pCO2 elevated, H2CO3 normal low

The correct answer is: pH decreased, pCO2 decreased, H2CO3 low

Metabolic acidosis is characterized by a decrease in arterial blood pH due to an increase in hydrogen ion concentration, which leads to a decrease in bicarbonate (HCO3-) levels. In this interpretation, the pH is decreased, indicating acidemia. The compensatory mechanism for metabolic acidosis involves the respiratory system, which decreases the partial pressure of carbon dioxide (pCO2) in response to the metabolic disturbance. This results in the pCO2 being decreased. Additionally, the concentration of bicarbonate (H2CO3, often represented in terms of its component bicarbonate ion HCO3-) will be low as it is one of the primary buffers that are reduced during metabolic acidosis. Therefore, the correct interpretation reflects a decrease in pH, a decrease in pCO2, and low bicarbonate levels, accurately illustrating the physiological changes that occur in metabolic acidosis.